Legalon contains a substance called silymarin, which has a powerful antioxidant effect. Thus, this substance can eliminate free radicals from liver cells and prevent further injury. Expected effect of the auxiliary drug in the treatment of liver diseases. In case of jaundice (yellowishness of the skin and whiteness of the eyes), consult a doctor immediately. Legalon® suspension comes in the form of thixotropic suspension, slightly yellowish, characteristic smell and bitter taste. Legalon is a liver protector used to treat digestive problems caused by liver disease and to prevent toxic liver damage caused, for example, by excessive consumption of alcoholic beverages. In addition, silymarin stimulates protein synthesis in liver cells that already have damage and normalizes phospholipid metabolism. The end result is that the cell membrane is stabilized by reducing and preventing the release of enzymes into the cytoplasm of the liver cell (e.g. transaminases). Silymarin restricts the entry of certain hepatotoxic substances into the cell (phalloides fungal poison of the amanita). The increase in protein synthesis by silymarin is due to the stimulation of RNA polymerase I, an enzyme located in the cell nucleus. This leads to an increase in ribosomal RNA formation with increased synthesis of structural and functional proteins (enzymes).

The result is an increase in the liver`s ability to rebuild and regenerate. The method of applying Legalon in tablet form is to take 1-2 capsules, 3 times a day, after meals, for 5-6 weeks or as directed by the doctor. Botanical nomenclature is a used component of the plant Carduus marianus L. (Compositae), fruit. Patients treated with silymarin for 90 days showed significant improvement in liver function compared to patients in the placebo group15. When using Legalon, cases of stomach pain, diarrhea and abdominal pain may occur. Exceptional allergic reactions can occur on the skin. This product contains sodium benzoate. The increase in bilirubin in the blood after its albumin displacement can increase neonatal jaundice, in which it can progress to an unconjugated bilirubin deposit in the brain tissue. The antitoxic efficacy of silymarin has been demonstrated in animal experiments in various models of liver injury, e.g.

with the poisons of Amanita phalloides, faloidine and amanitin, with lanthanides, carbon tetrachloride, galactosamine, thioacetamine and hepatotoxic viruses FV3. The therapeutic effects of silymarin are attributed to different mechanisms of action: excipients: citric acid, sorbitol, ascorbic acid, sodium benzoate, microcrystalline cellulose, carboxymethylcellulose, potassium sorbate, aluminum silicate and magnesium and purified water. This product contains the yellow dye tartrazine (capsule component), which may cause allergic reactions, including bronchial asthma, especially in people allergic to acetylsalicylic acid. Rare cases of gastralgia and diarrean episodes have been reported. Exceptionally, allergic skin reactions may occur. There are insufficient data on the use of this medicinal product in children. Therefore, it should not be used by children under 12 years of age. It is also important to mention that the Legalon leaflet warns that the drug does not replace the need to avoid the causes of liver problems such as taking alcohol and other substances. The main side effects of Legalon include skin allergies, difficulty breathing, abdominal pain and diarrhea. Legalon® SHAKING SUSPENDED BEFORE USE: Adolescents: 7.5 ml (1 1/2 teaspoon), 3 times a day. The product should be stored at room temperature (15°C to 30°C).

Concomitant use with other substances So far, there are no restrictions on the consumption of food or drink. To date, no symptoms associated with overdose have been reported. In case of accidental ingestion of doses well above the recommended doses, seek immediate medical attention. Do not take any action without first consulting a doctor. There is no specific antidote. The following side effects have been described: – Rare reactions (occurring in 0.1% to 1% of patients using this medicine): mild diarrhoea. – Very rare reactions (occur in less than 0.01% of patients using this drug): hypersensitivity (allergy), rash (rash), dyspnea (difficulty breathing). Tell your doctor, dentist or pharmacist about any side effects caused by the use of the medication. Also inform the company of its customer service.

Before use, observe the appearance of the drug. If it is on its expiry date and you notice a change in appearance, contact your pharmacist to find out if you can use it. Nycomed Pharma Ltda. Rodovia SP 340 S/N, Km 133.5 Jaguariúna – SP CNPJ 60.397.775/0008-40 Indústria Brasileira www.nycomed.com.br All medications should be kept out of the reach of children. There are no restrictions on the consumption of food or drink. In addition, silymarin stimulates protein synthesis in liver cells that are already damaged and normalizes phospholipid metabolism. The end result is the stabilization of the cell membrane, thereby reducing and preventing the release of enzymes into the cytoplasm of the liver cell (e.g. transaminases).

Each drágea contains 0.11 g of sugar in the form of sucrose. Legalon may cause side effects, however, herbal adverse reactions are rare or very rare, as shown below: Unless otherwise advised by a healthcare professional, the herbal medicine leaflet recommends starting treatment by taking one capsule three times a day. For the maintenance dose, the indication of the document is to take one capsule twice a day. In animals, silymarin has been shown to accelerate hepatic parenchyma regeneration and appear to increase RNA synthesis in the liver. Stopping treatment Do not stop treatment without your doctor`s knowledge. In other words, not everyone gets a reaction when using Legalon, and the likelihood of side effects is low. However, if you have any problems during treatment, talk to your doctor, especially if you experience severe symptoms. The effects on the ability to drive or use machines are not yet known. Do not use drugs with an expired shelf life. Keep it in its original packaging. Follow your doctor`s instructions, if the symptoms do not go away, consult a doctor. The product should be stored at room temperature (15°C to 30°C).

Batch number, date of manufacture and expiry date: see packaging. Do not use drugs with an expired shelf life. Keep it in its original packaging. The Legalon capsule comes in the form of a hard gelatinous capsule, a body and a transparent green cap containing yellowish beige powder. Legalon® capsule is for oral use only. This drug is manufactured by the pharmaceutical company Nycomed Pharma and can be purchased in conventional pharmacies in the form of tablets or syrup. COURT DECISIONS MS – 1.0639.0039 Firm. Contents: Rafael de Santis CRF-SP n° 55.728 Takeda Pharma Ltda. Rodovia SP 340 S/N km 133,5 – Jaguariúna – SP CNPJ 60.397.775/0008-40 Indústria Brasileira.

Concentration of active ingredient Each Drágea contains 70 mg of silymarin, calculated as silibin. Each capsule contains 140 mg of silymarin, calculated as silibinin.